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Table 1 SELECT and the approved ancillary studies

From: Opportunities and challenges in incorporating ancillary studies into a cancer prevention randomized clinical trial

 

Primary endpoint

Activation date

Last registration date

# men

# sites

Study site recruitment base

Follow-up procedure

SELECT

Prostate cancer

July 2001

June 2004

35,533

427

Cooperative Group; Veterans Admin Cooperative Studies program; sites involved in other large prevention trials (WHI, HOPE); Canadian urologic sites

Active follow-up every 6 months

PREADVISE

Alzheimer’s disease

May 2002

Sept 2009

7553

128

All invited

Active follow-up/memory screens

RAS

COPD

June 2004

April 2007

2921

18

20 sites with high proportion of smokers

Active follow-up/pulmonary function tests

SEE

Cataracts and AMD

July 2004

Dec 2009

2436

105

All invited

Medical record review

ACP

Colorectal adenomas

June 2008

May 2013

8089

76

100 sites with large number of men; men on Centralized Follow-up

Medical record review

  1. ACP Adenomatous Colorectal Polyps study, AMD age-related macular degeneration, COPD chronic obstructive pulmonary disease, PREADVISE Prevention of Alzheimer’s Disease with Vitamin E and Selenium, RAS Respiratory Ancillary Study, SEE SELECT Eye Endpoint study