Skip to main content

Table 3 Time schedule of participant engagement

From: Counteracting Age-related Loss of Skeletal Muscle Mass: a clinical and ethnological trial on the role of protein supplementation and training load (CALM Intervention Study): study protocol for a randomized controlled trial

Measurement

Enrollment

Baseline

6 months

12 months

18 months

Other

Enrollment

 Recruitment and screening

X

     

 Information and consent

X

     

Primary outcome

      

 MRI CSA of quadriceps femoris

 

X

X

X

X

 

Secondary outcomes

 Thigh isometric peak torque

 

X

X

X

X

 

 Thigh isokinetic peak torque

 

X

X

X

X

 

 Thigh power

 

X

X

X

X

 

 30-second chair-stand

 

X

X

X

X

 

 Muscle biopsy

 

X

 

X

  

 Body composition (DXA)

 

X

X

X

X

 

 Bone mineral density (DXA)

 

X

 

X

  

 Gut microbiome

 

X

X

X

  

 Fecal metabolome

 

X

X

X

  

 Plasma metabolome

 

X

X

X

  

 Acute muscle FSR

 

X

 

X

  

Tertiary outcomes

 Blood samples

 

X

X

X

X

 

 Anthropometry

 

X

X

X

X

 

 Hand grip strength

 

X

X

X

X

 

 400-m gait speed

 

X

X

X

X

 

 SF-36 and PSQI

 

X

 

X

  

 Activity monitoring

 

X

X

X

X

 

 Registration of food consumption

 

X

 

X

 

At week 6

 Sensory questionnaires

  

X

X

 

Weekly for 0–3 months

 Satisfaction with Food-related Life scale

 

X

X

X

  

 Oral glucose tolerance test

 

X

 

X

  

 Qualitative interview

 

X

  

X

 

 Questionnaire on food habits

 

X

    

 Life story interviews

     

Ad hoc

 Ethnographic fieldwork

     

Ad hoc

  1. Abbreviations: MRI CSA magnetic resonance imaging cross-sectional area, DXA dual-energy X-ray absorptiometry, FSR fractional synthesis rate, PSQI Pittsburgh Sleep Quality Index, SF-36 36-item Short Form Health Survey