Table 3 Primary, secondary, and other outcome measures

Primary outcome measures:

 • Mediterranean Diet Adherence Screener (MEDAS) score

 • Body mass index (BMI)

 • Ventilatory threshold 1 (VT1) determined by bicycle spiroergometry

For all three outcome measures, the change between baseline and 12 months will be analyzed.

Secondary outcome measures:

Psychology:

 • Stress coping capacity, as measured by the Trier Inventory for Chronic Stress (TICS) questionnaire

 • Grade of optimism, as measured by the Life Orientation Test (LOT) questionnaire

 • Quality of life, as measured by the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30)

Physical activity:

 • Maximum oxygen consumption (VO₂ peak), as measured by spiroergometry

 • Oxygen consumption (VO₂) and watts at ventilation threshold 1 (VT1 and VT2), as measured by spiroergometry

 • Physical activity, as measured by the International Physical Activity Questionnaire (IPAQ)

Nutrition:

 • Mediterranean Diet Adherence Screener (MEDAS) score

 • Dietary habits and calorie intake, as measured by the European Prospective Investigation into Cancer and Nutrition Study Food Frequency Questionnaire (EPIC-FFQ)

 • BMI

Breast cancer incidence and mortality

 • Breast cancer incidence

 • Overall and breast cancer mortality rate

Other outcome measures:

 • Attitudes and beliefs regarding physical training and healthy diet, as measured by the “Bewertung koerperlicher Aktivitaet und Ernaehrung” (BKAE) questionnaire

 • Satisfaction with the study

 • Body fat content, as measured by skinfold measurement

 • Tobacco and alcohol consumption

 • Omega 3, 6, and 9 fatty acids in the erythrocyte membrane

 • Serum cholesterol including serum high- and low-density lipoprotein cholesterol

 • Serum triglycerides, glucose, high-sensitivity C-reactive protein, and insulin

 • Serum proenkephalin and proneurotensin

 • Hospitalization days for breast cancer

If appropriate, secondary and other outcome measures will be analyzed as the change from baseline over time of all available time points.