| S-1226 (4 % CO2) (n = 9) | S-1226 (8 % CO2) (n = 9) | S-1226 (12 % CO2) (n = 9) | Placebo (n = 9) | Total (n = 36) |
---|---|---|---|---|---|
Severity | Â | Â | Â | Â | Â |
 Mild | 3 | 1 | 20 | 4 | 28 |
 Moderate | 0 | 0 | 0 | 0 | 0 |
 Severe | 0 | 0 | 0 | 0 | 0 |
Relationship to drug | Â | Â | Â | Â | Â |
 Probable | 0 | 0 | 0 | 0 | 0 |
 Possible | 1 | 0 | 6 | 0 | 7 |
 Remote | 1 | 1 | 3 | 1 | 6 |
 Unrelated | 1 | 0 | 11 | 3 | 15 |
Action taken | Â | Â | Â | Â | Â |
 Dose increased | 0 | 0 | 0 | 0 | 0 |
 Dose not changed | 3 | 1 | 18 | 2 | 24 |
 Dose reduced | 0 | 0 | 0 | 0 | 0 |
 Drug interrupted | 0 | 0 | 1 | 0 | 1 |
 Drug withdrawn | 0 | 0 | 0 | 0 | 0 |
 Not applicable | 0 | 0 | 1 | 0 | 3 |
 Unknown | 0 | 0 | 0 | 0 | 0 |