Table 3 Experiment 2: losses after intravenous injection, relative concentrations and actual doses after direct subcutaneous injection of different formulations of interferon β-1a
From: Biases affecting injected doses of an experimental drug during clinical trials
Formulation | Losses after intravenous injection | Relative concentration (direct subcutaneous injection) | Actual dose [MIU] (direct subcutaneous injection) | |||
|---|---|---|---|---|---|---|
Median | Range | Median | Range | Median | Range | |
Biferonex® HSA-free | 5.6 % | 0.6 % | 167 % | 3 % | 18.01 | 0.02 |
Biferonex® + HSA | 13.6 % | 6.5 % | 173 % | 8 % | 16.74 | 0.05 |
Rebif® | 5.7 % | 9.1 % | 131 % | 19 % | 18.33 | 0.01 |