Table 1 Criteria for identifying clinical trials that may benefit from accurate determination of doses administered
From: Biases affecting injected doses of an experimental drug during clinical trials
1 | Studies to determine a drug’s absolute clearance or volume parameters |
2 | Studies in which a drug is administered intravenously |
3 | Studies using a drug not manufactured according to industrial standards |
4 | Studies on peptides, proteins or other complex biological agents |
5 | Studies using immunologically based analytical methods |
6 | Studies using a parallel-group design, with qualitatively different treatments administered to each group |