Table 1 Models of different frequency distribution of AFD. Standard care distribution is based on data obtained from our validation cohort. The different models demonstrate increasing shifts in the frequency distribution towards more AFD in the sample. These distributions are illustrative, and different proportions in each category could give the same effect size. AFD antibiotic-free days
Proportion of AFD (%) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | N per arm | Effect size | |
Standard Care (from validation study) | 55 | 10 | 10 | 5 | 5 | 5 | 5 | 5 | ||
Model 1 | 40 | 20 | 15 | 5 | 5 | 5 | 5 | 5 | 215 | 0.033 |
Model 2 | 35 | 20 | 15 | 10 | 5 | 5 | 5 | 5 | 138 | 0.052 |
Model 3 | 30 | 20 | 15 | 10 | 10 | 5 | 5 | 5 | 96 | 0.075 |
Model 4 | 25 | 20 | 20 | 10 | 10 | 5 | 5 | 5 | 68 | 0.106 |