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Effectiveness of biomarker-based exclusion of ventilator-acquired pneumonia to reduce antibiotic use (VAPrapid-2): study protocol for a randomised controlled trial

  • Thomas P. Hellyer1Email author,
  • Niall H. Anderson2,
  • Jennie Parker3,
  • Paul Dark4,
  • Tina Van Den Broeck5,
  • Suveer Singh6,
  • Ronan McMullan7,
  • Ashley M. Agus8,
  • Lydia M. Emerson9,
  • Bronagh Blackwood9,
  • Savita Gossain10,
  • Tim S. Walsh11,
  • Gavin D. Perkins12,
  • Andrew Conway Morris13,
  • Daniel F. McAuley8, 9, 14 and
  • A. John Simpson1
Trials201617:318

https://doi.org/10.1186/s13063-016-1442-x

Received: 6 November 2015

Accepted: 24 June 2016

Published: 16 July 2016

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Open Peer Review reports

Pre-publication versions of this article are available by contacting editorial@trialsjournal.com.

Original Submission
6 Nov 2015 Submitted Original manuscript
10 Jan 2016 Reviewed Reviewer Report - Dirk Schaedler
22 Jan 2016 Reviewed Reviewer Report - Vinit Srivastava
29 Feb 2016 Author responded Author comments - Thomas Hellyer
Resubmission - Version 2
29 Feb 2016 Submitted Manuscript version 2
Publishing
24 Jun 2016 Editorially accepted
16 Jul 2016 Article published 10.1186/s13063-016-1442-x

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting info@biomedcentral.com.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
(2)
Centre for Population Health Sciences, University of Edinburgh, Medical School, Edinburgh, UK
(3)
Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK
(4)
Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Sciences Centre & Intensive Care Unit, Salford Royal NHS Foundation Trust, Greater Manchester, UK
(5)
Becton Dickinson Biosciences, Aalst, Belgium
(6)
Intensive Care Unit, Chelsea and Westminster Hospital, Imperial College London, London, UK
(7)
Department of Medical Microbiology, Kelvin Building, The Royal Hospitals, Belfast, UK
(8)
Northern Ireland Clinical Trials Unit, Elliot Dynes Building, The Royal Hospitals, Belfast, UK
(9)
Centre for Experimental Medicine, Queen’s University Belfast, Belfast, UK
(10)
Public Health Laboratory, Heart of England NHS Foundation Trust, Birmingham, UK
(11)
MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
(12)
University of Warwick and Heart of England NHS Foundation Trust, Coventry, UK
(13)
Division of Anaesthesia, Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge Biomedical Campus, Cambridge, UK
(14)
Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK

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