Inclusion criteria |
• Trauma patient received directly from the scene of the accident AND • Age ≥18 years AND • Initiated order of transfusion of at least one blood component within the first hour of arrival AND • Predicted to need transfusion package therapy during the initial resuscitation (first 2 hours) AND • Consent obtainable from patient or scientific guardians (independent physicians and/or next of kin) |
Exclusion criteria |
Patients are not eligible for inclusion in this trial if they fulfill one or more of the following criteria: • Duration of >2 hours from time of accident to arrival at trauma centre OR • Known anticoagulant treatment (vitamin K antagonist, dabigatran, rivaroxiban, apixaban) OR • Severe isolated traumatic brain injury OR • Moribund patient with devastating injuries and expected to die within 1 hour of admission OR • Withdrawal from active therapy OR • Previously, within 30 days, included in a randomized trial, if known at the time of enrolment OR • Known body weight <55 kg OR • Any blood product prior to inclusion |