Table 1 Required sample size per arm as a function of the coefficient of variation and the number of clinical centers
Coefficient of variation | Probability that π Si >0.225 | Number of clinical centers | ||||
|---|---|---|---|---|---|---|
20 | 40 | 60 | 80 | 100 | ||
0 | 1 | 610 | 580 | 560 | 540 | 520 |
0.1 | 0.99 | 660 | 600 | 580 | 560 | 530 |
0.2 | 0.90 | 880 | 700 | 650 | 600 | 560 |
0.3 | 0.79 | 1840 | 1000 | 800 | 700 | 640 |
0.4 | 0.71 | 50,000 | 1700 | 1200 | 900 | 800 |