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Table 2 Reasons for not completing the full year of medication

From: Towards onset prevention of cognition decline in adults with Down syndrome (The TOP-COG study): A pilot randomised controlled trial

Reason

Group allocation

Skin rash and GP advised to stop medication

Simvastatin

Weight loss, hitting leg – symptoms preceded taking the medication, but relative thought possibly worse so stopped medication

Simvastatin

Onset of thyroid dysfunction and carer chose to stop medication

Placebo

History of episodic diarrhoea. Diarrhoea after commencing medication so relative stopped medication

Simvastatin

GP prescribed a statin

Placebo

Paid carer withdrew consent

Simvastatin

Dementia diagnosed, and relative stopped medication

Placebo

Participant changed their mind

Placebo