Visit day | Pre-screen | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Days 8–13 | Day 14 | Day 15–41 | Day 42 | Days 43–89 | Day 90 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Check eligibility | x | |||||||||||||
Informed consent | x | |||||||||||||
Demographic data | x | |||||||||||||
Clinical details | x | |||||||||||||
Randomise | x | |||||||||||||
Ensure blood cultures are ordered by treating clinicians | x | x | x | (x)a | (x)a | (x)a | (x)a | |||||||
Ensure FBC, EUC, LFTs, CRP and vancomycin levels are ordered by treating clinicians | x | x | x | As clinically indicated | ||||||||||
Vancomycin or daptomycin doses | x | x | x | x | x | x | x | x | x | (x)b | (x)b | (x)b | ||
Combination therapy group: β-lactam doses | x | x | x | x | x | x | x | |||||||
Clinical progress assessment | x | x | x | x | Weekly whilst in hospital | x | ||||||||
Vital status (alive) | x | x | x | x | x | x | x | |||||||
Additional data review | x | x | x | x | x |