Table 2 Content and points of data capture

Day

0

1

2

3

4

5

6

7

8

28

Informed consent form

Χ

Pregnancy test

Χ

Demographic information

Χ

Inclusion/exclusion criteria

Χ

Get SSID and random number

Χ

History of SP and treatment

Χ

History of medication and treatment

Χ

Concomitant diseases

Χ

Complications

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Body weight and body mass index

Χ

Χ

Vital signs

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Laboratory tests

Χ

Χ

Χ

Safety outcomes

Χ

Χ

Χ

Χ

Mean arterial pressure

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Central venous pressure

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Blood gas analysis

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Mechanical ventilation parameters

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Chest x-ray or CT scan

Χ

Χ

Χ

Sputum and blood culture

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Record of routine treatment

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Issue study drug

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Record issue and recovery drug

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Record adverse events

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Severity-of-illness scores

Χ

Χ

Χ

Stage efficacy evaluation

Χ

Χ

Length of mechanical ventilation

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Length of stay in ICU

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Length of hospitalization

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Length of antibiotic use

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Χ

Efficacy and safety evaluation

Χ

Main treatment affecting prognosis

Χ

Survival follow-up

Χ