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Table 2 Sample size estimation based on four scenarios with small to medium effect sizes

From: Effectiveness and cost-effectiveness of a patient-initiated botulinum toxin treatment model for blepharospasm and hemifacial spasm compared to standard care: study protocol for a randomised controlled trial

Scenario

Effect size (d)

ICC

Standard care

Intervention

Time points

Alpha

Tails

Power

Scenario 1

0.25

0.3

115

115

4

0.05

2

0.80

Scenario 2

0.3

0.3

80

80

4

0.05

2

0.80

Scenario 3

0.35

0.3

59

59

4

0.05

2

0.80

Scenario 4

0.4

0.3

46

46

4

0.05

2

0.81