Comparison of exenatide with biphasic insulin aspart 30 on glucose variability in type 2 diabetes: study protocol for a randomized controlled trial

Table 1 Prebreakfast and predinner insulin titration regimens

Fasting and/or predinner SMBG PG value (mmol/L)	Adjustment
<5.0	-2 U
5.0 to 7.0	No adjustment
7.1 to 7.7	+2 U
7.8 to 10	+4 U
>10	+6 U

BG, blood glucose; SMGB, self-monitored blood glucose
Glycemic targets for titration: Prebreakfast and predinner PG: 5.0 to 7.0 mmol/L. Prebreakfast dose of biphasic insulin aspart 30 is titrated based on the three mean predinner PG values for the 3 days prior to the visit. Predinner dose of biphasic insulin aspart 30 is titrated based on the three mean fasting PG values for the 3 days prior to the visit. The predinner biphasic insulin aspart 30 titration is not increased if the preceding day’s bedtime SMGB value is 5.6 mmol/L

ISSN: 1745-6215