Trial eligibility criteria | Number of trials reporting criteria k (%), (k = 60) | Number of GENOA participants meeting criteria n (%), (n = 394) |
---|---|---|
Inclusion criteria | ||
 Age ≥18 | 30 (50.0) | 394 (100.0) |
 DSM-IV or ICD criteria for opioid dependence | 23 (38.3) | 394 (100.0) |
 Requirement of previous MMT Treatments or currently receiving methadone | 18 (30.0) | 394 (100.0) |
 Provision of positive opioid urine test | 18 (30.0) | / |
 Daily injecting drug use patterns or intravenous drug use behavior | 11(18.3) | 28 (7.1) |
 Addiction Severity Score (i.e., >8 on MAP or >12 on ASI) | 5 (8.3) | 168 (42.6) |
 Explicit willingness to follow methadone treatment regime | 4 (6.7) | 394 (100.0) |
 Educational requirements (high school diploma) | 4 (6.7) | 352 (89.3) |
 Abstinence from alcohol and other substances for 1 week prior to study entry | 3 (5.0) | / |
 Reported criminal behavior in last 6 months | 1 (1.6) | 24 (6.1) |
Exclusion criteria | ||
 Presence of psychiatric comorbidity | 36 (60) | 293 (74.4) |
 Presence of chronic physical comorbidity | 31 (51.7) | 225 (57.1) |
 Presence of acute physical problems | 30 (50.0) | 106 (26.9) |
 Presence of psychotropic or neuroleptic medication | 29 (48.3) | 193 (50.0) |
 Pregnancy | 27 (45.0) | / |
 Concurrent alcohol or substance abuse problems | 19 (31.7) | 293 (74.4) |
 Abnormal liver enzymes | 9 (15.0) | / |
 Presence of HIV | 1 (1.7) | 3 (0.76) |