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Table 4 Biochemical measurements on research specimens

From: Prevention of vitamin D deficiency in children following cardiac surgery: study protocol for a randomized controlled trial

Sample

Timepoint

Pre-treatmenta

During study drug administrationb

Preoperativec

Operating room prior to surgery

Postoperative

Blood

Vitamin Dd

Vitamin Dd

Vitamin Dd

Vitamin Dd

Vitamin Dd

 

Ionized calcium

Ionized calcium

Ionized calcium

Ionized calcium

   

VDBP

VDBP

   

PTH

PTH

   

Immune function

Immune function

   

(for example, cathelicidin)

(for example, cathelicidin)

   

Immune activity

Immune activity

   

(for example, cytokines)

(for example, cytokines)

Urine

Calcium to

-

-

Calcium to

Calcium to

 

Creatinine ratio

  

Creatinine ratio

Creatinine ratio

  1. aneonates, or < 2 months of supplement anticipated
  2. bany patient who receives > 6 months of supplement
  3. call outpatients who receive > 2 months of supplement
  4. d25OHD will be measured to indicate vitamin D status. The 25OHD level determined at the time of standard preoperative blood work, for safety purposes, will be ordered through the laboratory. The intraoperative and postoperative 25OHD measurements will be determined, using LC-MS/MS technology that adheres to and meets the standards of the Vitamin D External Quality Assessment Scheme