Inclusion criteria | Exclusion criteria |
---|---|
Diagnosis of TEN by all of the following: | Patients younger than 12 or older than 85 |
• Characteristic histologic findings on diagnostic biopsy | Patients who have documented: |
• Clinical diagnosis verified by two independent physicians | • Uncontrolled infection (for example, documented bacteremia) |
• Greater than 10 % eroded body surface area | • Malignancy |
• Negative pregnancy test in reproductive-age female patients | • Known prior immunodeficiency |
• Actively worsening disease (enlarging area of involvement or new erosions occurring over the previous 24 hours) | • Pregnancy |
• Patient body surface area > 1.0 m2 | • Concurrent use of systemic corticosteroids in the burn center greater than or equal to 0.5 mg/(kg day) or prednisone or equivalent dose of systemic corticosteroid |
 | • Greater than 70 % eroded skin |
• Hepatitis | |
 | • SCORETEN > 3 on admission |
 | • Active hepatitis, or alanine transaminase or aspartate aminotransferase above four times normal limits |
 | • Renal insufficiency (glomerular filtration rate < 50 ml/(min*1.73 m2)) |