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Table 1 Study inclusion and exclusion criteria

From: Topical clobetasol for the treatment of toxic epidermal necrolysis: study protocol for a randomized controlled trial

Inclusion criteria

Exclusion criteria

Diagnosis of TEN by all of the following:

Patients younger than 12 or older than 85

• Characteristic histologic findings on diagnostic biopsy

Patients who have documented:

• Clinical diagnosis verified by two independent physicians

• Uncontrolled infection (for example, documented bacteremia)

• Greater than 10 % eroded body surface area

• Malignancy

• Negative pregnancy test in reproductive-age female patients

• Known prior immunodeficiency

• Actively worsening disease (enlarging area of involvement or new erosions occurring over the previous 24 hours)

• Pregnancy

• Patient body surface area > 1.0 m2

• Concurrent use of systemic corticosteroids in the burn center greater than or equal to 0.5 mg/(kg day) or prednisone or equivalent dose of systemic corticosteroid

 

• Greater than 70 % eroded skin

• Hepatitis

 

• SCORETEN > 3 on admission

 

• Active hepatitis, or alanine transaminase or aspartate aminotransferase above four times normal limits

 

• Renal insufficiency (glomerular filtration rate < 50 ml/(min*1.73 m2))