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Table 2 Reproducibility and comparability of local BeneMin magnetic resonance imaging (MRI) protocols and N-back presentation

From: The benefit of minocycline on negative symptoms in early-phase psychosis in addition to standard care - extent and mechanism (BeneMin): study protocol for a randomised controlled trial

 

Wolfson Brain Imaging Centre Cambridge

MRI facility in Salford Royal NHS Foundation Trust

Wellcome Trust Centre for Neuroimaging UCL

Centre for Neuroimaging Sciences KCL

Clinical Research Imaging Centre Edinburgh

Birmingham University Imaging Centre

MRI scanner

Siemens Trim Trio

Philips Achieva

Siemens Trim Trio

GE

Siemens Verio

Philips Archieva

Field strength (Tesla)

3 T

3 T

3 T

3 T

3 T

3 T

Head Coil

12-channel

8-channel

12-channel

12-channel

12-channel

8-channel

MPRAGE/SPGR time

9:14

10:52

9:14

10:19

9:14

10:52

PD/T2 time

5:08

5:33

5:08

4:49

5:08

5:33

EPI time

25:02

25:04

25:00

25:04

25:02

25:08

MPRAGE/SPGR voxel size FH/IS (mm)

1

1

1

1

1

1

MPRAGE/SPGR voxel size AP (mm)

1

1

1

1

1

1

MPRAGE/SPGR voxel size RL (mm)

1

1.2

1.2

1.2

1.2

1.2

PD/T2 voxel size AP (mm)

0.9

0.9

0.9

0.9

0.9

0.9

PD/T2 voxel size RL (mm)

0.9

0.9

0.9

0.9

0.9

0.9

PD/T2 voxel size FH/IS (mm)

3

3

3

3

3

3

EPI voxel size RL (mm)

3

3

3

3.3

3.4

3

EPI voxel size AP (mm)

3

3

3

3.3

3.4

3

EPI voxel size FH/IS (mm)

4.5

4.5

4.5

4.5

4

4.5

FOV MPRAGE/SPGR FH/IS (mm)

256

256

256

260

256

256

FOV MPRAGE/SPGR AP (mm)

256 (240)

256 (240)

256 (240)

260

256 (240)

240

FOV MPRAGE/SPGR RL (mm)

192

204

192

204

176

204

FOV PD/T2 AP (mm)

240

240

240

240

240

240

FOV PD/T2 RL (mm)

240 (214)

240 (210)

240 (214)

240

240 (214)

210

FOV PD/T2 FH/IS (mm)

144

144

144

144

144

144

FOV EPI RL (mm)

192

192

192

211

220

192

FOV EPI AP (mm)

192

192

192

211

220

192

FOV EPI FH/IS (mm)

126

175.5

126

126

129

175.5

Slice plane MPRAGE/SPGR

Sagittal

Sagittal

Sagittal

Sagittal

Sagittal

Sagittal

Slice plane PD/T2

Transverse

Transverse

Transverse

Transverse/axial

Transverse

Transverse

Slice plane EPI

Transverse

Transverse

Transverse

Transverse/axial

Transverse > C-19.8 > S0.8

Transverse

EPI acquisition

Interleaved

Interleaved

Interleaved

Interleaved

Interleaved

Interleaved

Number of slices for MPRAGE/SPGR

176

170

160

170

160

170

Number of slices for PD/T2

48

48

48

48

48

48

Number of slices for EPI

28

39

28

28

26

39

Number of volumes for EPI

748

748

748

748

748

748

Fold-over/phase encoding direction MPRAGE/SPGR

A > > P

A > > P

A > > P

P > > A

A > > P

A > > P

Fold-over/phase encoding direction PD/T2

R > > L

R > > L

R > > L

L > > R

R > > L

R > > L

Fold-over/phase encoding direction EPI

A > > P

A > > P

A > > P

P > > A

A > > P

A > > P

TE MPRAGE/SPGR (ms)

2.98

Shortest (3.1)

2.91

Min Full

2.98

3.1

TR PD/T2 (ms)

3,000

3,000

3,000

3,000

3,000

3,000

TE 1 PD/T2 (ms)

11

Shortest (10)

11

Min Full

11

Shortest (10)

TE 2 PD/T2 (ms)

99

96

99

97.2

101

96

TR EPI (ms)

2,000

2,000

2,000

2,000

2,000

2,000

TE EPI (ms)

30

30

30

30

26

30

Flip angle MPRAGE/SPGR (deg)

9

8

9

8

9

8

Flip angle EPI (deg)

90

79

90

90

66

79

Distance factor for EPI (%)

0

0

0

0

25 (1 mm)

0

MRI data format

DICOM

DICOM

DICOM

DICOM

DICOM

DICOM

N-back task software

Visual studio

E-Prime 2.0.10

E-Prime 2.0.10

E-Prime 2.0.10 Professional

E-Prime 2.0.10

E-Prime 2.0.10 Professional

Response pad

4-button right handed

4-button right handed

4-button right handed

4-button right handed

4-button right handed

5-button right handed

Response box connection

Parallel port

USB

USB

USB

USB

USB

TTL pulses box connection

Parallel port

USB

USB

USB

USB

Parallel port

N-back data format

TXT

TXT

TXT

TXT

TXT

TXT

  1. NHS, National Health Service; UCL, University College London; KCL, King’s College London; GE, General Electric; FH/IS, foot-to-head/inferior-to-superior; AP, anterior-to-posterior; RL, right-to-left; FOV, field of view; A > > P, from anterior to posterior; P > > A, from posterior to anterior; R > > L, from right to left; L > > R, – from left to right; TE, echo time; TR, repetition time; TTL, transistor-transistor logic.