Table 1 SHINE two-sided P values for stopping for success or futility at each interim analysis
From: The Stroke Hyperglycemia Insulin Network Effort (SHINE) trial: an adaptive trial design case study
Information fraction | SuccessPValue | FutilityPValue |
|---|---|---|
36% | 0.003 | 0.949 |
50% | 0.004 | 0.896 |
64% | 0.008 | 0.652 |
78% | 0.016 | 0.293 |
100% | 0.043 | 0.043 |