Parameters | SEA | SEI | FOR | ONO | 5-O-M | AST-IV |
---|---|---|---|---|---|---|
t 1/2 (h) | 22.72 ± 11.49 | 12.35 ± 10.3 | 51.24 ± 44.19 | 7.04 ± 3.7 | 42.79 ± 16.29 | 11.41 ± 12.51 |
C max (ng/ml) | 53.71 ± 16.14 | 136.51 ± 45.24 | 9.39 ± 4.32 | 2.45 ± 1.51 | 0.14 ± 0.07 | 13.3 ± 5.42 |
T max (h) | 0.22 ± 0.07 | 0.31 ± 0.16 | 0.22 ± 0.07 | 0.25 ± 0.00 | 0.25 ± 0.00 | 2.00 ± 2.25 |
AUClast(h*ng/ml) | 606.87 ± 161.89 | 851.3 ± 251.31 | 38.1 ± 8.04 | 4.17 ± 1.53 | 1.13 ± 0.10 | 107.74 ± 65.65 |
AUCtot(h*ng/ml) | 826.3 ± 229.51 | 900.76 ± 236.67 | 71.57 ± 26.49 | 4.89 ± 1.65 | 2.31 ± 0.41 | 129.75 ± 61.01 |
MRT (h) | 36.54 ± 15.27 | 16.58 ± 6.89 | 70.4 ± 60.63 | 9.55 ± 4.04 | 65.96 ± 20.60 | 17.9 ± 17.38 |
CL (L/h/kg) | 0.05 ± 0.01 | 0.02 ± 0.01 | 0.02 ± 0.00 | 0.12 ± 0.05 | 0.16 ± 0.03 | 0.06 ± 0.07 |
V z (L/kg) | 1.41 ± 0.67 | 0.41 ± 0.33 | 0.98 ± 0.43 | 1.12 ± 0.83 | 9.38 ± 2.09 | 0.83 ± 0.94 |