- Paper Report
- Open Access
Statins reduce dementia risk by 70%
- Joanna Lyford1
© Biomed Central Ltd 2001
- Received: 19 October 2001
- Published: 19 October 2001
- Dimentia, statins
A case-control study of British over-50s has found that those taking statins have a substantially reduced risk of developing dementia. This supports a large observational study reported earlier this year, which found an inverse relationship between treatment with pravastatin or lovastatin and incidence of Alzheimer's disease.
Among the controls, 13% had untreated hyperlipidemia, 11% were prescribed statins, 7% other lipid-lowering agents (LLA) and 69% had no hyperlipidemia or LLA exposure. The relative risk estimates of dementia (adjusted for age, sex, coronary artery disease, hypertension, coronary bypass surgery, cerebral ischemia, smoking and body mass index) for individuals with untreated hyperlipidemia (odds ratio 0.72, 95% CI 0.45-1.14) or treated with non-statin LLAs (0.96, 0.47-1.97) was not significant compared with people who had no diagnosis of hyperlipidemia or exposure to other lipid-lowering drugs. The adjusted relative risk for those prescribed statins was 0.29 (0.13-0.63, P = 0.002).
The authors used the UK General Practice Research Database to identify 284 patients with dementia; each case was then matched with up to four controls matched for age, sex, practice and date.