- Paper Report
- Open Access
Caerphilly study finds no link between homocysteine and CHD
- Joanna Lyford1
© Biomed Central Ltd 2001
- Received: 18 October 2001
- Published: 18 October 2001
- Coronary disease, homocysteine, risk factors
This study investigates the hypothesis that a raised homocysteine concentration is an independent risk factor for coronary heart disease (CHD).
The mean follow up period was 10 years, 312 CHD events occurred during follow-up, of which 172 were fatal. The geometric mean serum homocysteine concentration was higher in cases (12.2 ?mol/l, 95% CI 11.8-12.6 ?mol/l) than in controls (11.8 ?mol/l, 95% CI 11.3-12.5 ?mol/l) (P <0.09). There was a graded increase in the odds ratio of CHD across quintiles of the homocysteine concentration distribution compared with the first (P = 0.04), which was attenuated when adjusted for confounding variables (P = 0.4). Comparing the top quintile of the homocysteine concentration with the remaining 80%, the adjusted odds ratio of coronary heart disease was 1.03 (95% CI 0.73-1.45) (P = 0.8) and comparing the top 5% with the remaining 95% it was 1.05 (95% CI 0.56 -1.95) (P = 0.9).
Between 1979 and 1983, the researchers recruited male residents of Caerphilly, South Wales, who were aged 45-59 years at baseline. In the present study, 2290 men who had homocysteine levels measured in 1994 were included in the analysis.