- Paper Report
- Open Access
Orbofiban in unstable angina (OPUS-TIMI 16 trial)
- Gethin Ellis1
© Biomed Central Ltd 2001
- Received: 13 September 2000
- Published: 17 October 2001
- Orbofiban, unstable andgina
This paper describes the effects of prolonged glycoprotein IIb/IIIa inhibition with oral orbofiban on the composite end point of death, myocardial infarction, recurrent ischaemia requiring hospitalisation, urgent revascularisation or stroke in patients with acute coronary syndromes (ACS). This research was undertaken because whilst intravenous glycoprotein IIb/IIIa inhibitors have been shown to be beneficial in patients with ACS, the effects of prolonged oral inhibition of this receptor have not been previously described.
In patients with ACS, orbofiban had no effect on the primary composite end point and was associated with increased mortality; the trial was terminated prematurely. Subgroup analysis suggested that patients who underwent percutaneous coronary intervention had a lower mortality rate and a significant reduction in the composite end point.
ACS is defined as ischaemic pain at rest within 72 h of randomisation, associated with positive cardiac markers, electrocardiographic changes, or prior cardiovascular disease. In total, 10,288 patients in 29 countries were randomised into three groups to receive either 50 mg orbofiban twice daily, 50mg of orbofiban twice daily for 30 days followed by 30 mg of orbofiban twice daily, or a placebo. All patients received aspirin.
- Cannon CP, McCabe CH, Wilcox RG, Langer A, Caspi A, Berink P, Lopez-Sendon J, Toman J, Charlesworth A, Anders RJ, Alexander RJ, Skene A, Braunwald E: Oral glycoprotein IIb/IIIa inhibition with orbofiban in patients with unstable coronary syndromes (OPUS-TIMI 16) trial. Circulation. 2000, 102: 149-156.View ArticlePubMedGoogle Scholar