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Table 4 Novel immunosuppressive strategies

From: New immunosuppressive drugs in heart transplantation

Site of action

Agent

Human studies

Interruption of TCR/MHC

  

binding

  

   CD4/MHC class II

Anti-CD4 mAbs

Yes

Interruption of T cell

  

co-stimulation

  

   CD28/B7

CTLA4-Ig

Yes (psoriasis)

   CD40/CD154

Anti-ICAM-1 mAbs

Yes (ITP)

Interruption of cell adhesion

  

   LFA-1/ICAM-1

Anti-LFA-1 mAbs

Yes

 

Anti-ICAM-1 mAbs

Yes

Interruption of accessory

  

molecule interactions

  

   CD2/LFA-3

Anti-LFA-3 mAbs

No

 

Anti-CD2 mAbs

Yes

   CD45

Anti-CD45

Yes

  1. ICAM-1, intracellular adhesion molecule-1; ITP, idiopathic thrombocytopenic purpura; LFA, lymphocyte function associated antigen; mAb, monoclonal antibody; MHC, major histocompatibility complex; TCR, T cell receptor.