Site of action | Agent | Human studies |
---|---|---|
Interruption of TCR/MHC | Â | Â |
binding | Â | Â |
   CD4/MHC class II | Anti-CD4 mAbs | Yes |
Interruption of T cell | Â | Â |
co-stimulation | Â | Â |
   CD28/B7 | CTLA4-Ig | Yes (psoriasis) |
   CD40/CD154 | Anti-ICAM-1 mAbs | Yes (ITP) |
Interruption of cell adhesion | Â | Â |
   LFA-1/ICAM-1 | Anti-LFA-1 mAbs | Yes |
 | Anti-ICAM-1 mAbs | Yes |
Interruption of accessory | Â | Â |
molecule interactions | Â | Â |
   CD2/LFA-3 | Anti-LFA-3 mAbs | No |
 | Anti-CD2 mAbs | Yes |
   CD45 | Anti-CD45 | Yes |