Use of diffusion and perfusion magnetic resonance imaging as a tool in acute stroke clinical trials

Table 3 Magnetic resonance imaging as a biomarker of clinical status [29]

Acute lesion volumes correlated with clinical scales and with final
lesion volumes
Strong association of reduction in lesion volume with clinical
improvement:^*
	% patients	Median	Mean
Clinical	with lesion	change	change
improvement	decrease^†	(cm³)^‡	(SE) (cm³)^†
Yes	74	-2.8	3.8 (3.8)
No	36	3.7	25.5 (6.8)

^*Week 12 minus baseline lesion volume change related to clinical improvement (n = 81, from [29]). SE, standard error. ^†P < 0.001; ^‡P < 0.01.

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