TRIAL | SPECIALTY | POPULATION | MANAGEMENT | RECRUITMENT SETTING | INTERVENTIONS | DESIGN | FUNDERS |
---|---|---|---|---|---|---|---|
HPS (The H eart P rotection S tudy) | Cardiovascular health promotion | Patients at increased risk of coronary heart disease | Clinical Trials Unit | Hospital | - Statins (Simvastatin) -Antioxidant vitamins - Placebo | 4 arm randomised trial (2 × 2 factorial) | MRC BHF Industry |
FOCUS (Trial of Chemotherapy for Bowel Cancer (F luorouracil, O xaliplatin and Irinotecan (C PT11), U se and S equencing) | Oncology | Patients with advanced metastatic colorectal cancer | Clinical Trials Unit | Hospital | Chemotherapeutic agents - Modified de gramont with fluorouracil - Irinotecan - Oxaliplatin | 5 arm randomised trial with cross-over | MRC Industry NHS Trusts |
ELEVATE (A pragmatic single-blind RCT and health economic evaluation of leukotriene receptor antagonists in primary care at steps two and three of the National Asthma Guidelines) | Asthma management | Primary care patients with asthma requiring regular preventative treatment or an increase in therapy | University Department | General Practice | - Leukotriene receptor antagonists - Inhaled corticosteroids - long-acting beta agonists | 3 arm randomised trial (with option to switch treatments post-randomisation and parallel non-randomised 'naturalistic' cohort for patients refusing randomisation) | HTA Industry PCTs |
TOuCAN (T rial of O utcome for C hild &A dolescent Anorexia N ervosa) | Adolescent psychiatry | Adolescents (aged 12–18) with anorexia nervosa | Hospital/university | Hospital and out-patient service | - intensive inpatient treatment - general local outpatient service - specialist outpatient service | 2 severity strata (steps) with 2 arms at each step | HTA |