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Table 2 Percent change in lumbar spine BMD in ovariectomized rats after 12 weeks of treatment with nitroglycerin (NTG) ointment 29.

From: The effects of organic nitrates on osteoporosis: a randomized controlled trial [ISRCTN94484747]

Treatment Group (n = 5 for all groups)

Change in Lumbar Spine BMD

Sham operated

6.3% ± 5.3 *

Ovariectomy (OVX)

-2.5% ± 2.0

OVX + estrogen

5.9% ± 3.4*

OVX + 0.2 mg nitroglycerin ointment once a day

6.2% ± 2.8*

OVX + 0.2 mg nitroglycerin ointment twice a day

1.9% ± 2.1

OVX + 0.2 mg nitroglycerin ointment three times a day

-0.2% ± 3.3