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A review of the online prognositc model predict using the POSH cohort (women aged ≤40 years at breast cancer diagnosis)
Trials volume 16, Article number: P36 (2015)
Breast cancer is the most common cancer women in the UK, with approximately 50,000 new cases each year. PREDICT (http://www.predict.nhs.uk) is an online prognostic tool developed to help determine the best available treatment and long-term outcome for early breast cancer. This study was conducted to establish how well PREDICT performs in estimating survival in a large cohort of younger women (aged ≤40 years) recruited to the POSH study.
The UK POSH cohort includes data from 3000 women aged ≤40 years at breast cancer diagnosis. Study endpoints were overall- and breast cancer specific-survival at 5-,8-, and 10-years. Evaluation of PREDICT included model discrimination and comparison of the number of predicted versus observed events.
PREDICT provided accurate long term (8- and 10-year) survival estimates for younger women. However, short term (5-year) estimates were less accurate, with the tool overestimating survival by 25%, and by 56% for patients with ER positive tumours. PREDICT also underestimated survival at 5-years for patients with ER negative tumours.
PREDICT is a user-friendly and reliable tool for providing accurate long-term survival estimates for younger women with breast cancer. However, the model requires further calibration for more accurate short-term estimates. Prediction in the short-term may be most relevant for the increasing number of women considering risk-reducing bilateral mastectomy.
Funding for data collection/analysis of the POSH study by CRUK (grants A7572, A11699, C1275/A15956). Study sponsored by UHS NHS Foundation Trust. We also thank the NIHR NCRN for supporting patient recruitment and all participating patients.
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Maishman, T., Copson, E., Stanton, L. et al. A review of the online prognositc model predict using the POSH cohort (women aged ≤40 years at breast cancer diagnosis). Trials 16, P36 (2015) doi:10.1186/1745-6215-16-S2-P36
- Breast Cancer
- Young Woman
- Large Cohort
- Common Cancer
- Early Breast Cancer