The MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine

Table 3 Patient- and physician-oriented outcomes by domain and data source in the MedSeq project

	Data source
	Patient surveys	Patient interviews	Physician surveys	Physician interviews	Physician checklist	Audio recordings	EHR review	GRC logbook
Attitudes and preferences
Attitudes about project[48]	✓	✓		✓
Attitudes about sequencing[13]	✓	✓		✓
Perceived utility	✓	✓	✓	✓	✓
Preferences for information	✓	✓
Understanding
Understanding of consent[49, 50]	✓	✓	✓	✓		✓
Understanding of results	✓	✓				✓
Genetic self-efficacy[51]	✓		✓
Genetic literacy[52]	✓	✓	✓	✓
Health and risk perceptions[53]	✓
Psychological impact
General anxiety and depression[30]	✓
Results-specific affect[54]	✓
Intolerance of uncertainty[55]	✓
Behavioral impact
Health behaviors and intentions[56]	✓	✓			✓
Insurance coverage[57]	✓	✓
Medication and supplement use	✓	✓			✓		✓
Information seeking and sharing[58]	✓	✓		✓	✓			✓
Health-care utilization
Willingness to pay	✓		✓
Shared decision-making[59]	✓	✓		✓		✓
Follow-up testing and screening[60]	✓	✓		✓	✓	✓	✓	✓
Decisional satisfaction
Satisfaction[61]	✓	✓		✓
Decisional regret[62]	✓	✓		✓
Expectations	✓	✓		✓

References indicate published scales used in the design of the data collection instruments for the MedSeq Project. EHR, electronic health record; GRC, Genome Resource Center.

ISSN: 1745-6215