From: The MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine
Genome report | Cardiac risk supplement |
---|---|
Known pathogenic or likely pathogenic Mendelian variants, including some high-grade variants of uncertain significance resolvable by clinical evaluation | Predicted lipid profile (fasting low-density lipoprotein and high-density lipoprotein cholesterol and triglycerides) derived from polygenic model |
Carrier status for Mendelian diseases | Aggregate genetic risk associated with eight cardiometabolic traits from genome-wide association studies |
Pharmacogenomic associations for five commonly used medications: | Aortic aneurysm |
Warfarin | Atrial fibrillation |
Clopidogrel | Coronary artery disease |
Digoxin | Hypertension |
Metformin | Obesity |
Simvastatin | Platelet aggregation |
Genetic prediction of blood type with partial serological confirmation | QT prolongation |
 | Type 2 diabetes |