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Table 2 Characteristics of the included randomised questions

From: Comparison of anticipated and actual control group outcomes in randomised trials in paediatric oncology provides evidence that historically controlled studies are biased in favour of the novel treatment

Characteristics of included RQs (Nā€‰=ā€‰48)

Values

Year of publication (based on 40 publications), median (range)

2005 (1976 to 2010)

Trial type and primary outcome type

Ā 

ā€ƒSuperiority, timetoevent

31

ā€ƒEquivalence/noninferiority, timetoevent

11

ā€ƒSuperiority, dichotomous

6

Power

Ā 

ā€ƒMedian (range)

80% (73% to 99%)

ā€ƒNumber of trials <80%

6

Ī±

Ā 

ā€ƒMedian (range)

5% (5% to 20%)

ā€ƒNumber of trials >5%

3

Ī” (superiority), median (range)

15% (6% to 25%)

Noninferiority margin, median (range)

10% (7% to 17%)

Total design sample size, median (range)

240 (92 to 1,800)

Total recruited sample, median (range)

221 (36 to 2,618)