Variable/outcome | Hypothesis | Outcome measure | Methods of analysis |
---|---|---|---|
1) Primary | Intervention improved outcome from baseline to 7 days | Adherence% (>80%) [binary] | |
Diopter | Diopter reduced or increased after treatment | Diopter [continuous] | t-test (rank-sum test) or repeated measurement |
2) Secondary | Intervention improved outcome from baseline to 7 days | Adherence% (>80%) [binary] | |
Visual acuity | Visual acuity did not increase or decrease after treatment | Visual acuity changes [continuous] | t-test (rank-sum test) or repeated measurement |
Axial length | Axial length was not increased | Axial length changes [continuous] | t-test (rank-sum test) or repeated measurement |
Lens thickness | Lens thickness was not increased | Lens thickness changes [continuous] | t-test (rank-sum test) or repeated measurement |
Ciliary body thickness | Ciliary body thickness was not increased | Ciliary body thickness changes [continuous] | t-test (rank-sum test) or repeated measurement |
Eye symptoms and systemic symptoms | No adverse symptoms | No adverse symptoms | Chi-squared test or Fisher’s exact test |
Compliance | Compliance | Cure rate [binary] | Chi-squared test or Fisher’s exact test |
Combination therapy/treatment | Improvement occurred | Whether other drugs were used during treatment [binary] | Chi-squared test or Fisher’s exact test |
Adverse event | Improvement occurred | Presence of drug-related adverse event [binary] | Chi-squared test or Fisher’s exact test |
3) Baseline analyses: | Adherence% (>80%) [continuous] | ||
Age | CRF [continuous] | t-test (rank-sum test) | |
Weight and height | CRF [continuous] | t-test (rank-sum test) | |
Female versus male | CRF [binary] | Chi-squared test or Fisher’s exact test | |
Race | CRF [more categories] | Chi-squared test or rank-sum test | |
Birth weight | CRF [continuous] | t-test (rank-sum test) | |
Preterm children | CRF [binary] | Chi-squared test or Fisher’s exact test | |
Parental myopia or not | CRF [binary] | Chi-squared test or Fisher’s exact test | |
Sibling myopia or not | CRF [binary] | Chi-squared test or Fisher’s exact test | |
Daily close reading time | CRF [continuous] | t-test (rank-sum test) | |
Outdoor time | CRF [continuous] | t-test (rank-sum test) | |
Eye exercises every day or not | CRF [binary] | Chi-squared test or Fisher’s exact test | |
Daily sleep time | CRF [continuous] | t-test (rank-sum test) | |
Room light conditions | CRF [binary] | Chi-squared test or Fisher’s exact test | |
Poor reading habits | CRF [more categories] | Chi-squared test or rank-sum test |