From: The trials methodological research agenda: results from a priority setting exercise
Round 2 (32 responders) | Round 3 (24 responders) | |||||||
---|---|---|---|---|---|---|---|---|
Topic | 1 to 3 | Scores* 4 to 6 | 7 to 9 | 1 to 3 | Scores* 4 to 6 | 7 to 9 | ||
% responders | % responders | Consensus? | Rank | |||||
Methods to boost recruitment | 0.0 | 43.8 | 56.3 | 0.0 | 16.7 | 83.3 | Consensus in | 1 |
Choosing appropriate outcomes to measure | 3.1 | 28.1 | 68.8 | 0.0 | 29.2 | 70.8 | Consensus in | 2 |
Methods to minimise attrition | 6.3 | 40.6 | 53.1 | 0.0 | 29.2 | 70.8 | Consensus in | 2 |
Methods to minimise bias in trials when blinding is not possible | 0.0 | 40.6 | 59.4 | 0.0 | 33.3 | 66.7 | 4 | |
Pragmatic trials | 0.0 | 56.3 | 43.8 | 0.0 | 45.8 | 54.2 | 5 | |
Design and analysis of pilot/feasibility trials | 6.3 | 46.9 | 46.9 | 4.2 | 41.7 | 54.2 | 6 | |
Calculating sample size | 21.9 | 31.3 | 46.9 | 12.5 | 33.3 | 54.2 | 7 | |
Methods for dealing with missing data | 3.1 | 59.4 | 37.5 | 0.0 | 58.3 | 41.7 | 8 | |
Phase II trials | 15.6 | 50.0 | 34.4 | 16.7 | 50.0 | 33.3 | 9 | |
Complex interventions | 3.1 | 62.5 | 34.4 | 0.0 | 70.8 | 29.2 | 10 | |
Consent in emergency settings | 12.5 | 46.9 | 40.6 | 0.0 | 70.8 | 29.2 | 10 | |
Methods for trial monitoring | 9.4 | 65.6 | 25.0 | 8.3 | 62.5 | 29.2 | 12 | |
Adjustment for non-adherence to treatment protocol | 6.3 | 53.1 | 40.6 | 4.2 | 70.8 | 25.0 | 13 | |
Stratified medicine design | 6.3 | 56.3 | 37.5 | 8.3 | 66.7 | 25.0 | 14 | |
Primary care trials | 18.8 | 56.3 | 25.0 | 12.5 | 62.5 | 25.0 | 15 | |
Interim analysis/Data Monitoring issues | 9.4 | 65.6 | 25.0 | 0.0 | 79.2 | 20.8 | 16 | |
Adaptive designs | 0.0 | 62.5 | 37.5 | 4.2 | 75.0 | 20.8 | 17 | |
Equivalence/non-inferiority trials | 12.5 | 62.5 | 25.0 | 12.5 | 66.7 | 20.8 | 18 | |
Dealing with clustering effects | 6.3 | 65.6 | 28.1 | 4.2 | 79.2 | 16.7 | 19 | |
Methods for economic analysis | 12.5 | 65.6 | 21.9 | 8.3 | 75.0 | 16.7 | 20 | |
Cluster trials | 12.5 | 62.5 | 25.0 | 12.5 | 70.8 | 16.7 | 21 | |
Evaluation of electronic data capture methods | 28.1 | 50.0 | 21.9 | 20.8 | 62.5 | 16.7 | 22 | |
e-trials | 12.5 | 62.5 | 25.0 | 8.3 | 79.2 | 12.5 | 23 | |
Multi-arm Multi-stage (MAMS) designs | 12.5 | 75.0 | 12.5 | 12.5 | 75.0 | 12.5 | 24 | |
Stepped wedge designs | 15.6 | 65.6 | 18.8 | 16.7 | 75.0 | 8.3 | 25 | |
Randomisation methods | 34.4 | 53.1 | 12.5 | 33.3 | 58.3 | 8.3 | 26 | |
Multiplicity | 15.6 | 81.3 | 3.1 | 8.3 | 87.5 | 4.2 | 27 | |
Radiotherapy study designs | 59.4 | 34.4 | 6.3 | 75.0 | 20.8 | 4.2 | Consensus out | 28 |