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Table 2 Time-dependent quantitative results for the GOG111 trial

From: An approach to trial design and analysis in the era of non-proportional hazards of the treatment effect

Quantity

t=2 yr

t=5 yr

 

Est.

95% CI

Est.

95% CI

HR (t)

0.71

(0.57,0.89)

0.99

(0.71,1.39)

S 0(t)

0.52

(0.46,0.58)

0.18

(0.13,0.23)

S 1(t)

0.68

(0.62,0.73)

0.27

(0.22,0.33)

S 1(t)-S 0(t)

0.16

(0.07,0.24)

0.09

(0.02,0.16)

RMST 0 (yr)

1.53

(1.45,1.61)

2.44

(2.22,2.67)

RMST 1 (yr)

1.73

(1.66,1.79)

3.04

(2.81,3.26)

RMST 1- RMST 0

0.20

(0.09,0.30)

0.59

(0.27,0.91)

  1. Note that the estimated hazard ratio, HR(t), is instantaneous. See text for further details.
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Trials

ISSN: 1745-6215