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Figure 2 | Trials

Figure 2

From: An approach to trial design and analysis in the era of non-proportional hazards of the treatment effect

Figure 2

Time-dependent outcome measures exemplified by the PATCH1 trial: (a) Kaplan- Meier curves (solid lines) and estimated survival functions (dashed lines) from a flexible parametric model; (b) difference in survival functions; (c) instantaneous hazard ratio; (d) difference in restricted mean survival time. Shaded areas are pointwise 95 intervals. Estimates in panels (b), (c) and (d) are derived from a flexible parametric model. Follow-up has been truncated at 3 years.

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Trials

ISSN: 1745-6215