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Figure 1 | Trials

Figure 1

From: Vancomycin versus daptomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteremia due to isolates with high vancomycin minimum inhibitory concentrations: study protocol for a phase IIB randomized controlled trial

Figure 1

Study schematic. Vancomycin will be dosed intravenously at 15 mg/kg Q12h with appropriate dose adjustments by a pharmacist in patients with a creatinine clearance of less than 50 ml/min. Trough levels will be monitored pre-third or fourth dose (inclusive of doses received prior to study enrolment) and doses will be adjusted accordingly by a pharmacist to achieve a trough level of 15 to 20 ug/ml. Subsequently, vancomycin trough levels will be monitored at least every seven days (+/-three days) but additional levels may be required for dose titration at the discretion of the pharmacist or the managing physician.

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Trials

ISSN: 1745-6215