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Table 3 Feasibility outcomes and estimated sample sizes

From: Furosemide and albumin for diuresis of edema (FADE): a study protocol for a randomized controlled trial

Outcome Demonstration of feasibility Estimated actual proportion Desired precision Required sample size
Administration of first dose of albumin within two hours of furosemide administration Lower-bound of 95% confidence interval greater than 85% 0.925 0.075 47
Administration of at full 72 hours of study treatment Lower-bound of 95% confidence interval greater than 80% 0.9 0.1 34
Absence of hyperoncotic albumin in control arm Lower-bound of 95% confidence interval greater than 85% 0.95 0.1 18
Randomization rate of patients eligible by screening criteria Lower-bound of 95% confidence interval greater than 50% 0.65 0.15 39