Skip to main content

Table 1 Studies evaluating 25% albumin vs. placebo for the diuresis of critically ill patients

From: Furosemide and albumin for diuresis of edema (FADE): a study protocol for a randomized controlled trial

Reference

Type of study

Study population

Study intervention

Study outcome

[14]

Non-randomized trial

Surgical ICU patients

Salt-poor albumin (n = 8) versus furosemide alone (n = 5); all patients received furosemide

Improved oxygenation as measured by ADO2 at 2 hours

[17]

Retrospective observational study

Medical ICU patients (n = 31)

Case patients received 25% albumin; control patients did not; all patients received furosemide infusion

No change in urine output or fluid balance

[18]

Randomized controlled trial

Mechanically ventilated patients with congestive heart failure ( n = 30)

250 mg frusemide diluted in 12.5 g albumin at a rate of 0.1 mg frusemide/kg/hour versus furosemide infusion alone

No difference in urine output or fluid balance at 24 hours

[15]

Retrospective observational study

ICU patients

Cases patients (n = 30) received at least four doses of 100 ml 25% albumin; control patients (n = 25) received no albumin

No change in oxygenation, hemodynamics; higher positive fluid balance in cases

[19]

Randomized controlled trial

Mechanically ventilated patients with ARDS ( n = 40)

100 ml of 25% albumin every 8 hours versus placebo; furosemide infusion

Improved oxygenation, greater net negative fluid balance, better maintenance of hemodynamic stability

[16]

Prospective matched case-control study

Mechanically ventilated patients with acute lung injury or ARDS

Case patients (n = 57) received 200 ml of 20% albumin and Lasix infusion; control patients (n = 57) received usual care

Lower net fluid balance, shorter ICU stay, reduced duration of mechanical ventilation; lower mortality

  1. Randomized trials highlighted in bold text. ADO2, alveolar-arterial oxygen difference; ARDS, acute respiratory distress syndrome; ICU, intensive care unit.