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Table 1 Studies evaluating 25% albumin vs. placebo for the diuresis of critically ill patients

From: Furosemide and albumin for diuresis of edema (FADE): a study protocol for a randomized controlled trial

Reference Type of study Study population Study intervention Study outcome
[14] Non-randomized trial Surgical ICU patients Salt-poor albumin (n = 8) versus furosemide alone (n = 5); all patients received furosemide Improved oxygenation as measured by ADO2 at 2 hours
[17] Retrospective observational study Medical ICU patients (n = 31) Case patients received 25% albumin; control patients did not; all patients received furosemide infusion No change in urine output or fluid balance
[18] Randomized controlled trial Mechanically ventilated patients with congestive heart failure ( n= 30) 250 mg frusemide diluted in 12.5 g albumin at a rate of 0.1 mg frusemide/kg/hour versus furosemide infusion alone No difference in urine output or fluid balance at 24 hours
[15] Retrospective observational study ICU patients Cases patients (n = 30) received at least four doses of 100 ml 25% albumin; control patients (n = 25) received no albumin No change in oxygenation, hemodynamics; higher positive fluid balance in cases
[19] Randomized controlled trial Mechanically ventilated patients with ARDS ( n= 40) 100 ml of 25% albumin every 8 hours versus placebo; furosemide infusion Improved oxygenation, greater net negative fluid balance, better maintenance of hemodynamic stability
[16] Prospective matched case-control study Mechanically ventilated patients with acute lung injury or ARDS Case patients (n = 57) received 200 ml of 20% albumin and Lasix infusion; control patients (n = 57) received usual care Lower net fluid balance, shorter ICU stay, reduced duration of mechanical ventilation; lower mortality
  1. Randomized trials highlighted in bold text. ADO2, alveolar-arterial oxygen difference; ARDS, acute respiratory distress syndrome; ICU, intensive care unit.