Examination of mechanisms (E-MECHANIC) of exercise-induced weight compensation: study protocol for a randomized controlled trial

Table 1 Schedule of study procedures ^a

Evaluations and procedures		Baseline	Week 4	Week 24
Evaluations and procedures	Screening	(day −14 to day 0)	(day 28 to day 35)	(day 160 to day 174)
Informed consent and HIPAA authorization	OR, SV1
Randomization		Day 0
Anthropometrics and body composition
Height	RI1, SV1
Waist and hip circumference	SV1		Day 28	Days 160, 174
Weight	RI1, SV1	Days −14, −7, 0	Days 28, 35	Days 160, 167, 174
Blood pressure and heart rate	RI1, SV1		Day 28	Days 160, 174
ECG	SV1			Day 160
DXA		Day −14, 0		Days 160,174
Energy metabolism
TEE based on DLW measurement		Day −14		Day 160
Daily weight		Day −14 to day 0		Day 160 to day 174
Urine collection		Days −14, −7, 0		Days 160, 167, 174
RMR		Day −14		Day 160
Physical activity
Accelerometry	RI2	Day −14	Day 28	Day 160
VO₂max	SV2			Day 163
Psychological questionnaires^b		Day −14	Day 28	Day 160
Clinical chemistry panel (CBC, chem 15)	SV1			Day 160
Food intake tests with VAS		Day −4	Day 28	Day 170
Blood collection for satiety hormone archive^c		Day −4		Day 170

^aCBC, Complete blood count; chem 15, Panel of laboratory tests measuring 15 blood chemistry components; DLW, Doubly labeled water; DXA, Dual-energy X-ray absorptiometry; ECG, Electrocardiography; HIPAA, Health Insurance Portability and Accountability Act; OR, Orientation; RI, Run-in; RMR, Resting metabolic rate; SV, Screening visit; TEE, Total energy expenditure; VAS, Visual Analogue Scale; VO₂max, Maximal oxygen uptake. ^bThe Psychological questionnaires to be used are the Activity Temperament Questionnaire, Body Morph Assessment, Compensatory Health Beliefs Scale, Eating Inventory, Food Craving Inventory, Food Preference Questionnaire, Medical Outcomes Study 36-item Short Form, Multifactorial Assessment of Eating Disorder Symptoms, Pittsburgh Sleep Quality Index, Retrospective Visual Analogue Scale, Yale Food Addiction Scale. ^cBefore and after food intake tests.

ISSN: 1745-6215