Figure 1From: Toward onset prevention of cognitive decline in adults with Down syndrome (the TOP-COG study): study protocol for a randomized controlled trial Flowchart of the study protocol. AE, Adverse event; APO E, apolipoprotein E; AR, Adverse reaction; CYP3A4, Cytochrome P450 3A4; GG&C, NHS Greater Glasgow & Clyde; OD, Once daily; RCT, Randomized controlled trial; SAR, Serious adverse reaction.Back to article page