Figure 1

General overview of EMDADER-TAB ^a study. ^aEMDADER-TAB: Efecto del Método Dader de Seguimiento Farmacoterapéutico en pacientes con Trastorno Afectivo Bipolar I. (Effectiveness of Dader Method for pharmaceutical care in patients with bipolar I disorder]. ^bThe randomization takes place during week zero (baseline) and, during the first 20 days, the pharmacist will reinforce the information related to treatment adherence and ask the patient and his relatives for some criteria that will allow assessing treatment effectiveness and safety. In addition, the pharmacist will make two phone calls (week 1 and 3 from baseline) and a home visit (week 2 from baseline) to assess the variables related to the primary (number of hospitalizations, emergency service consultations, unscheduled outpatient visits) and secondary outcomes (effectiveness, safety, adherence, quality of life). Patients will meet again with the pharmacist every 3 months (3, 6, 9, and 12 months).