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Table 1 Cure proportions for 10,000 simulated trials using conventional and proposed trial designs

From: Randomized clinical trials to identify optimal antibiotic treatment duration

Trial design and treatment

Number of subjects

Treatment duration (weeks)

Cure proportion

Conventional trial design

   

Standard regimen

700

NA

0.90

Regimen A

700

14

0.90

Proposed alternative trial design

   

Standard regimen

700

NA

0.90

Regimen A

100

14

0.80

Regimen A

100

16

0.84

Regimen A

100

18

0.87

Regimen A

100

20

0.90

Regimen A

100

22

0.92

Regimen A

100

24

0.94

Regimen A

100

26

0.95