From: Randomized clinical trials to identify optimal antibiotic treatment duration
Trial design and treatment | Number of subjects | Treatment duration (weeks) | Cure proportion |
---|---|---|---|
Conventional trial design | Â | Â | Â |
Standard regimen | 700 | NA | 0.90 |
Regimen A | 700 | 14 | 0.90 |
Proposed alternative trial design | Â | Â | Â |
Standard regimen | 700 | NA | 0.90 |
Regimen A | 100 | 14 | 0.80 |
Regimen A | 100 | 16 | 0.84 |
Regimen A | 100 | 18 | 0.87 |
Regimen A | 100 | 20 | 0.90 |
Regimen A | 100 | 22 | 0.92 |
Regimen A | 100 | 24 | 0.94 |
Regimen A | 100 | 26 | 0.95 |