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Table 3 Mortality in FEAST A presented in each IDMC report

From: When enough is enough: how the decision was made to stop the FEAST trial: data and safety monitoring in an African trial of Fluid Expansion As Supportive Therapy (FEAST) for critically ill children

  Comparisons between arms for mortality at 48 hours
  Mortality in each arm   Primary endpoint Secondary endpoint
Meeting Albumin Saline Control Total Risk ratio for saline bolus versus no bolus Risk ratio for albumin bolus versus saline bolus Risk ratio bolus versus no bolus
18 June 2009 (data to 13 May 2009); N = 406 12/137 (8.8%) 14/136 (10.3%) 18/133 (13.5%) 44/406 (10.8%) 0.76 (0.39 to 1.47);P = 0.41 0.87 (0.42 to1.81); P = 0.71 0.70 (0.40 to 1.24); P = 0.22
12 October 2009 (data to 31 August 2009); N = 844 30/283 (10.6%) 28/282 (9.9%) 31/279 (11.1%) 89/844 (10.5%) 0.89 (0.06 to 1.45); P = 0.65 1.07 (0.66 to 1.74); P = 0.79 0.92 (0.61 to 1.39); P = 0.71
26 January 2010 (data to 31 December 2009); N = 1,337 50/444 (11.3%) 46/445 (10.3%) 43/448 (9.6%) 139/1337 (10.4%) 1.07 (0.73 to 1.60); P = 0.71 1.09 (0.75 to 1.59); P = 0.66 1.13 (0.78 to 1.58); P = 0.50
26 July 2010 (data to 15 June 2010); N = 2,196 74/732 (10.1%) 74/733 (10.1%) 56/731 (7.7%) 204/2196 (9.3%) 1.32 (0.95 to 1.84); P = 0.10 1.001 (0.74 to 1.36); P = 0.99 1.32 (0.98 to 1.77); P = 0.06
12 January 2011 (data to 15 November 2010); N = 2,987 101/989 (10.2%) 101/989 (10.2%) 69/989 (7.0%) 271/2987 (9.1%) 1.46 (1.09 to 1.96);P = 0.01 1.00 (0.77 to 1.30); P = 1.0 1.46 (1.13 to 1.90);P = 0.004