Table 1 Inclusion and exclusion criteria

Inclusion criteria:

1. Patients with DES implanted, then treated with clopidogrel plus aspirin for 12 months

2. Informed, written consent from the patient

Exclusion criteria:

1. Age <18 years

2. Oral anticoagulation therapy

3. Drug-eluting stent in an unprotected left main coronary artery

4. Contemporaneous enrollment in a different clinical trial

5. Malignancies or other comorbid conditions with a life expectancy <2 years

6. Known allergy or intolerance to the study medications: aspirin and/or clopidogrel

7. Other revascularization with a DES within nine months prior to this study

8. Other revascularization with a BMS within four weeks prior to this study