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Table 1 Chemotherapy procedure of both groups

From: Assessing the effectiveness and safety of liposomal paclitaxel in combination with cisplatin as first-line chemotherapy for patients with advanced NSCLC with regional lymph-node metastasis: study protocol for a randomized controlled trial (PLC-GC trial)

Group

Day

Intervention

Dosage

Route of administration

Treatment (LP)

1

Liposomal paclitaxel

135 to 175 mg/m2 in saline (500 ml)1

IV drip (over 3 hours)

  

Cisplatin

75 mg/m2 in saline (500 ml)2

IV drip

Control (GP)

1 and 8

Gemcitabine

1000 mg/m2 in saline (100 ml)

IV drip (over 30 min)

 

1

Cisplatin

75 mg/m2in saline (500 ml)2

IV drip

  1. Abbreviations: GP, gemcitabine plus cisplatin; IV, intravenous; LP, liposomal paclitaxel.
  2. 1In the LP group, the liposomal paclitaxel must be used before cisplatin to avoid myelosuppression.
  3. 2At least 1500 ml of saline should be used for hydration before cisplatin infusion occurs.