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Table 1 Composition and action of Ma Zi Ren Wan (MZRW)

From: Chinese herbal medicine (Ma Zi Ren Wan) for functional constipation: study protocol for a prospective, double-blinded, double-dummy, randomized controlled trial

Ingredients

%

g/sachet

g/day

Action

Fructus Cannabis

35.7

10.8a

21.7

TCM: Moistening the bowel and relieving constipation

    

Pharmaceutical study: 1. Purgative effect, 2. Hypotensive effect

Radix et Rhizoma Rhei

17.9

5.4

10.9

TCM: Draining heat and relieving constipation

    

Pharmaceutical study: 1. Purgative effect, 2. Antimicrobial effect, 3. Antineoplastic and ant mutagenic effect, 4. Hemostatic effect, 5. Immunosuppressive effect, 6. Choleretic effect

Semen Armeniacae Amarum

17.9

5.4

10.9

TCM: Reliving constipation by guiding Qi downward

    

Pharmaceutical study: 1. Laxative effect, 2. Antitussive and antiasthmatic effect, 3. Analgesic effect, 4. Antineoplastic and antimutagenic effect

Radix Paeoniae Albo

8.9

2.7

5.4

TCM: Nourishing Yin and retaining homeostasis

    

Pharmaceutical study: 1. Analgesic effect, 2. Antimicrobial and anti-inflammatory effect, 3. Immunologic effect

Cortex Magnoliae Officinalis

10.7

3.3

6.5

TCM: Promoting circulation of Qi and relieving flatulence

    

Pharmaceutical study: 1. Central muscle-relaxation effect, 2. Anti-emetic effect, 3. Anti-ulcerative effect 4. Central inhibitory effect, 5. Antimicrobial effect

Fructus Aurantll Immaturus

8.9

2.7

5.4

TCM: Promoting circulation of Qi and relieving flatulence

    

Pharmaceutical study: 1. Diuretic effect, 2. Two-way effect on gastrointestinal smooth muscle, 3. Cardiovascular stimulating effect

  1. TCM, traditional Chinese medicine.
  2. aEach gram of MZRW granule is equivalent to 4.05 g of raw herbs.