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Table 1 Baseline characteristics of patients

From: Effects of a multifaceted intervention on cardiovascular risk factors in high-risk hypertensive patients: the ESCAPE trial, a pragmatic cluster randomized trial in general practice

Characteristic

Intervention (n = 905)

Usual care (n = 927)

Male, n (%)

575 (63.5)

589 (63.5)

Mean age, years (SD)

62.1 (7.9)

62.4 (7.7)

Height, cm (SD)

166.9 (9.3)

167.4 (9.1)

Weight, kg (SD)

85.8 (16.5)

85.6 (15.9)

Body Mass Index, kg/m2 (SD)

30.7 (5.2)

30.5 (5.0)

Men with waist ≥ 102 cm, n (%)

358 (62.8)

385 (66.3)

Women with waist ≥ 88 cm, n (%)

279 (85.6)

278 (85.3)

Mean systolic blood pressure, mmHg (SD)a

145.9 (15.3)

138.7 (13.5)

Mean diastolic blood pressure, mmHg (SD)a

83.7 (11.7)

80.6 (9.2)

Heart rate, beats/min (SD)

71.4 (10.9)

71.6 (10.4)

Total cholesterol, mmol/l (SD)

5.27 (1.15)

5.29 (1.14)

HDL, mmol/L (SD)

1.30 (0.35)

1.32 (0.37)

LDL, mmol/L (SD)

3.19 (1.02)

3.21 (1.04)

Triglyceride, mmol/L (SD)

1.84 (1.19)

1.78 (1.00)

Creatininemia μmol/L (SD)

86.2 (29.9)

85.4 (25.5)

MDRD-estimated glomerular filtration rate, ml/min (SD)

79.6 (19.6)

80.8 (20.2)

Fasting glycemia, mmol/l (SD)

6.88 (1.94)

6.77 (1.94)

Left ventricular hypertrophy, n (%)

150 (16.6)

184 (19.9)

Family history of early cardiovascular event, n (%)

225 (24.9)

253 (27.3)

Albuminuria ≥ 20 mg/L, n (%)

186 (22.3)

154 (18.1)

Mean years since diagnosis of hypertension (SD)

10.5 (7.8)

11.2 (8.3)

Smoker status

  

  Current n (%)

193 (21.3)

217 (23.4)

  Past smoker < three years n (%)

72 (8.0)

94 (10.2)

  Non-smoker n (%)

640 (70.7)

615 (66.4)

Number of antihypertensive drugs, n (SD)

2.16 (1.04)

2.18 (1.04)

Type-2 diabetes, n (%)

527 (58.2)

521 (56.2)

Mean years since diagnosis of type-2 diabetes, (SD)

6.9 (6.1)

7.8 (6.9)

HbA1c, % (SD)

7.0 (1.1)

7.0 (1.2)

Cardiovascular risk factors, n (%)

  

Men > 50 or women > 60 years old

779 (86.1)

802 (86.6)

Current smoker or past smoker < three years

265 (29.3)

311 (33.6)

LDL ≥ 4.14 mmol/L or treatment

692 (76.5)

686 (74.0)

HDL ≤ 1.04 mmol/L

189 (20.9)

190 (20.6)

Number of cardiovascular risk factors, n (%)

  

  ≤ 2

259 (28.6)

264 (28.5)

  3

319 (35.2)

315 (34.0)

  4

222 (24.5)

247 (26.6)

  ≥ 5

105 (11.6)

101 (10.8)

Ten-year Framingham-Anderson risk score, (%)

17.5

17.0

Achieved all therapeutic targets (3 or 5), n/N (%)a

56/900 (6.2)

94/923 (10.2)

Achieved blood pressure target, n (%)a

207 (23.0)

392 (42.6)

Achieved LDL target, n (%)

370 (41.1)

395 (43.4)

No smoking, n (%)

712 (78.7)

709 (76.6)

Patients with diabetes

  

Achieved HbA1c target n/N (%)

312/527 (60.1)

316/521 (61.7)

Low-dose aspirin (yes) n/N (%)a

225/527 (42.7)

140/521 (26.9)

  1. astatistically significantly different between groups (P < 0.001).
  2. MDRD, modified diet in renal disease; SD, standard deviation.