Table 1 Definition of early and late treatment failures

(i) Development of danger signs or severe malaria on day 0, day 1, day 2 or day 3, in the presence of parasitemia

Late treatment failure is divided into late clinical and late parasitological failure

(ii) Parasite density on day 2 > day 0 count, irrespective of tympanic temperature

Late clinical failure:

(iii) Presence of parasitemia on day 3 with fever (tympanic temperature ≥ 38.0°C)

(i) Development of danger signs or severe malaria after day 3 in the presence of parasitemia

(iv) Parasitemia on day 3 ≥ 25% of count on day 0

(ii) Presence of parasitemia and fever on any day from day 4 to day 28, without having previously met the criteria of early treatment failure

Late parasitological failure:

Parasitemia after day 3 in the absence of fever (tympanic temperature <38.0°C) and without having previously met the criteria of early treatment failure or late clinical failure