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Table 2 Examples of adjustment of raw P values using fallback procedure and Hommel’s procedure

From: Detailed statistical analysis plan for the target temperature management after out-of-hospital cardiac arrest trial

Weight

Raw P value (example 1)

Fallback procedure

Hommel’s procedure

Raw P value (example 2)

Fallback procedure

Hommel’s procedure

0.5

0.030

0.060

0.055

0.030

0.060

0.030

0.25

0.010

0.040

0.050

0.010

0.040

0.0225

0.0625

0.015

0.048

0.055

0.015

0.048

0.030

0.0625

0.055

0.0629

0.055

0.001

0.016

0.0040

0.0625

0.055

0.0629

0.055

0.001

0.016

0.0040

0.0625

0.055

0.0629

0.055

0.001

0.016

0.0040

  1. Based on these considerations the analyses in the TTM trial will be presented with unadjusted P values as well as adjusted for multiplicity using the fallback procedure.